What is PX50 & DX100?

PX50™ & DX100™
are part of Skye’s BioRenew® PTM Therapy™ product line, and are designed specifically for treating in-office non-operative conditions, sports medicine and interventional applications. PTM Therapy™ products are derived from donated human placentas, and provide a complete, high-performance biologic solution to effectively support the body’s natural regenerative process.

blackdrop spacer2 Provides a native human placental
BioActive® ECM

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blackflow spacer2 Designed as a ready to use fluid in the vial

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blackone spacer2 One-time treatment

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blacktime spacer2 No tissue draw or spin down time


Where is PTM Therapy applied?

PTM Therapy
is used to treat patients who are suffering from various injuries and degenerative conditions, by supplementing or replacing the damaged or inadequate connective tissue at the injury site . Many of these conditions are very painful, result in limited mobility, are difficult to heal, and may lead to surgery if left untreated. Common connective tissue injuries include:

• Degenerative Disc Disease

• Rotator Cuff & Labral Tears

• Calcific Tendon, Frozen Shoulder

• Facet Joint Disorders

• Sacroiliac (SI) Joint Dysfunction

• Tennis Elbow, UCL Strains

• Stress Fractures

• Bursitis, Synovitis

• Tendinitis, Tendinosis

• Knee & Hip Osteoarthritis

• ACL, PCL, Meniscus Tears

• Degenerated Joints

• Tendon, Ligament, Muscle Strains

• Turf Toe, Hallux Limitus

• Plantar Fasciitis, Heel Pain
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How does PTM Therapy work?

PTM Therapy™
replaces the body’s damaged or missing connective tissue at the area of injury with a highly-functioning ExtraCellular Matrix derived from the placental source. The ExtraCellular Matrix is the interconnected system of Collagens, Growth Factors, and Bioactive molecules that provides the structural foundation for our body’s tissues and biochemical support to the surrounding cells.1,2



What are potential benefits of PTM Therapy?



Is it proven to work?

BioRenew® PTM Therapy™
has been shown to successfully treat a variety of injuries and painful chronic conditions. The following chart measures the pain score reduction achieved following treatment of lower extremity tendon injuries, in a published clinical study3.



How does PTM Therapy compare to other ‘amniotic’ products?

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Amniotic Fluid Products
Some processors make product simply from the amniotic fluid. This fluid is 98% water, and collects some of the biologic components of the placenta during pregnancy, making it a secondary and diluted source of these biologic components.
Amniotic Membrane Particulates
Other processors grind up amniotic membrane wound coverings, creating a limited biologic powder or ‘injectable’.white spacer
PX50™ & DX100™
PTM Therapy™
Only Skye Biologics provides a complete placental biologic solution, with the complete range of beneficial components from the placental source, in a fluid form.
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What are the indications of these amniotic and placental treatments?

Amniotic Fluid
Intended for use as a viscosupplement4
spacer2 Amnion Membrane Particulates
Indicated for use only as a wound covering
PX50™ & DX100™
Intended for all areas of damaged or inadequate connective tissue


Connective tissue has broad application, as it is the most prolific tissue type in the human body; it creates our skin, tendons, ligaments, cartilage and bone, wraps nerves and lines the other tissue layers.

What are the storage options of these treatments?

Amniotic Fluid

Cryopreserved Only

spacer2 Amnion Membrane Particulates
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Cryopreserved Only

PX50™ & DX100™


and Ambient

Only PTM Therapy™ is offered in both Cryopreserved (frozen) and the industry’s first Room Temperature option

What do Other Types of ‘Regenerative’ Treatments Provide?

Only PTM Therapy provides a complete biologic solution, derived from the natural placental source.


Provides concentrated hyaluronans, for use as a viscosupplement.

white spacer Platelet-Rich Plasma


Provides concentrated growth factors from the patient’s blood. Requires a needle to draw the blood.

spacer2 Adipose Stem Cells


Manually concentrates cells from the patient’s fat tissue. Requires a liposuction procedure to source the fat.

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Manually concentrates cells from the patient’s bone marrow. Requires a surgical procedure with sedation to draw the marrow.
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Available Sizes

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How to Order

phone white spacer Call us: 310.796.5680
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[1-4] References on file.

NOTE Skye Biologics, Inc. make no claims concerning the biological properties of any product or potential outcomes as a result of the use of any product. Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. The results reported may not necessarily occur in all individuals. Skye Biologics is providing this site and its contents on an “as is” basis and makes no representations or warranties of any kind with respect to this site or its contents. All tissues have been collected, processed, stored and distributed in compliance with FDA regulations governing HCT/Ps.